A new study presented at the European Society of Cardiology's EHRA 2025 Congress has raised serious concerns about the long-term use of antidepressants (ADs). Researchers found a significant correlation between extended use of ADs and an increased risk of sudden cardiac death (SCD), especially among younger individuals.

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SCD risk linked to antidepressant use

• Among 643,999 people prescribed ADs in Denmark, 1,981 cases of sudden cardiac death were recorded, compared to 4,021 among 4.3 million unexposed individuals.

• Individuals using antidepressants for 1–5 years had a 56% higher risk of SCD compared to the general population.

• Risk was 2.2 times higher for users with more than 6 years of antidepressant exposure.

Younger individuals face greater impact

• For those aged 30–39, SCD risk was nearly 3 times higher with 1–5 years of exposure and up to 5 times higher for over 6 years.

• In the 50–59 age group, the risk doubled with 1–5 years of use and quadrupled with longer use.

• The risk leveled off slightly in individuals above 70 years.

Experts call for more research and monitoring

• Dr Jasmin Mujkanovic from Rigshospitalet Hjertecentret, Copenhagen, emphasized that longer antidepressant use correlates with higher SCD risk.

• The risk could stem from drug effects, severity of underlying illness, or lifestyle factors linked to depression such as delayed care and poor heart health.

While antidepressants are essential for many patients, this study highlights the importance of cautious long-term use, particularly among younger adults. Physicians are advised to regularly evaluate cardiovascular risk and explore alternative therapies when feasible. Further research is crucial to understand the underlying mechanisms and mitigate risks associated with extended antidepressant use.