The topical drug PP405, developed by Pelage Pharmaceuticals, has shown encouraging results in Phase 2a clinical trials for hair regrowth. Unlike traditional treatments such as minoxidil or finasteride, PP405 works at the cellular level by reactivating dormant hair follicle stem cells, stimulating natural hair growth, and restoring scalp density. Early studies indicate visible hair regrowth even in previously bald areas, with minimal side effects, making it a potentially safe and long-term solution for hair thinning and bald patches.

Key highlights

Mechanism of action

• Increases lactate availability in the scalp to energize dormant follicle stem cells.

• Reactivates inactive hair follicles to produce new strands naturally.

• Works locally on the scalp with minimal systemic absorption.

Clinical trial results

• Phase 2a trial included 78 participants applying PP405 daily for eight weeks.

• 31% of participants saw more than 20% increase in hair density.

• Improvements reported in hair thickness, texture, and scalp coverage.

• Minimal side effects observed, confirming safety for long-term use.

Advantages over conventional treatments

• Targets the root cause of hair loss, not just hair shedding or circulation.

• Provides natural and long-lasting hair regrowth, not temporary cosmetic thickening.

• Potentially effective for androgenetic alopecia and general thinning, in both men and women.

Future outlook

• Phase 3 trials expected in 2026 to evaluate efficacy in a larger population.

• If successful, PP405 could become the first treatment capable of reactivating dormant follicles instead of masking hair loss.

• Full market availability may take 5–7 years due to regulatory approvals.

PP405 represents a breakthrough in hair restoration, offering pharmacists and healthcare providers a future tool for addressing hair loss at the source. By targeting follicle stem cells and promoting natural hair regrowth, this drug could redefine hair care and treatment for millions of patients struggling with baldness or thinning hair.